Job ID: #9406

Principal Scientist, Pharmacology (Oligonucleotides)

Boston, MA
Science Science
Research & Development

Located in Boston, MA


Responsibilities of the Principal Scientist, Pharmacology (Oligonucleotides):

  • Lead the development, optimization, and execution of in vitro and in vivo nonclinical pharmacology studies.
  • Establish in vitro and in vivo pharmacology models and assays.
  • Identify CRO and academic partners for in vitro and in vivo pharmacology studies and establish collaborations.
  • Manage nonclinical development studies for enhanced delivery oligonucleotides to support pre-candidate and early and late development programs in-house and at contract research organizations.
  • Partner with Research Project Team leaders, CMC, Toxicology, Bioanalytical, and Biomarkers functions in the design and interpretation of nonclinical pharmacology and efficacy studies as they relate to assessment of PK/PD.
  • Manage associate scientists and scientific team members.
  • Maintain clear technical records and prepare summary presentations and reports of ongoing activities for both internal and external audiences.


Requirements of the Principal Scientist, Pharmacology (Oligonucleotides):

  • PhD in biomedical science, biochemistry, biology, or related discipline with at least 6+ years of relevant experience in the pharmaceutical industry in preclinical drug discovery and development.
  • Experience with in vitro and in vivo preclinical disease models and developing medium-throughput assay formats to support drug development.
  • Proficient in techniques, including method development and optimization, critical for molecular and cellular biology experiments e.g., protein and nucleic acid extraction and gene expression analysis by RT-PCR, qPCR and/or digital PCR, western blotting, and ISH.
  • Experience with managing and/or conducting studies with CROs.

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    Commonwealth Sciences is a professional recruiting firm specializing in Life Science, Medical Device, and Engineering Technologies. We unite industry professionals with exciting career opportunities by leveraging our technical expertise, advanced recruiting tools and years of staffing experience. CWS works with a variety of disciplines and levels from Research Associates to Scientists, Engineers, Managers and Directors. Our clients value the basic integrity, customer service and industry expertise that defines our organization.