Located in Cambridge, MA

Responsibilities of the Principal Associate Scientist/Scientist (RNA Synthesis):

• Synthesis, purification, and analysis of mRNAs and mRNA components.
• Chromatographic purification of mRNA to be used in research and pre-clinical evaluation.
• Write, review, and approve protocols, SOPs, technical documents, and reports for mRNA manufacturing.
• Independently plan and execute experiments and perform data analysis and interpretation.
• Deliver reproducible and impactful results in a fast-paced environment.
• Maintain thorough electronic lab notebooks and documentation records and present findings to multi-disciplinary teams in various oral and written formats.

Requirements of the Principal Associate Scientist/Scientist (RNA Synthesis):

• BS or MS in Chemistry, Biochemistry, Chemical Engineering, or closely related fields with 5+ years industry experience or a PHD with 0-3 years of experience.
• Expertise in in vitro transcription of RNA.
• Experience purifying (anion exchange, reversed phase, size exclusion chromatography and TFF) nucleic acids.
• Experience and/or working understanding of common techniques used to analyze oligonucleotides, such as HPLC/UPLC, UV/Fluor, CD, and LC-MS.