Job ID: #9419

Principal Scientist/Scientist (RNA Synthesis)

Cambridge, MA
Science Science
Research & Development

Located in Cambridge, MA


Responsibilities of the Principal Associate Scientist/Scientist (RNA Synthesis):

  • Synthesis, purification, and analysis of mRNAs and mRNA components.
  • Chromatographic purification of mRNA to be used in research and pre-clinical evaluation.
  • Write, review, and approve protocols, SOPs, technical documents, and reports for mRNA manufacturing.
  • Independently plan and execute experiments and perform data analysis and interpretation.
  • Deliver reproducible and impactful results in a fast-paced environment.
  • Maintain thorough electronic lab notebooks and documentation records and present findings to multi-disciplinary teams in various oral and written formats.


Requirements of the Principal Associate Scientist/Scientist (RNA Synthesis):

  • BS or MS in Chemistry, Biochemistry, Chemical Engineering, or closely related fields with 5+ years industry experience or a PHD with 0-3 years of experience.
  • Expertise in in vitro transcription of RNA.
  • Experience purifying (anion exchange, reversed phase, size exclusion chromatography and TFF) nucleic acids.
  • Experience and/or working understanding of common techniques used to analyze oligonucleotides, such as HPLC/UPLC, UV/Fluor, CD, and LC-MS.

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