Located in Cambridge, MA

Responsibilities of the Scientist – LNP Formulation:

• Development, optimization, and troubleshooting of LNP/mRNA formulation processes at various scales.
• Develop new assays or detailed investigations of specific LNP attributes as required.
• Screen final formulation buffers and excipients to improve the long-term stability of LNPs.
• Maintain up-to-date records and prepare internal reports.
• Characterize LNP formulations and components using Dynamic Light Scattering, Ribogreen, HPLC, etc.
• Analyze, summarize, and present experimental results to team members and management.
• Maintain stocks and supplies for the operation of the Process Development Functions.
• Participate in technology transfer activities related to manufacturing processes and/or analytical methods to external partner programs.
• Contribute to technical discussions & intellectual property.
• Characterize the mRNA encapsulated LNPs for their size, zeta potential, morphology, encapsulation efficiency, integrity, and stability using relevant assays (DLS, TEM, Ribogreen, CE, AGE, PAGE, UV-VIS, HPLC, etc.).
• Work closely with mRNA synthesis, LNP/RNP formulation, and in vitro and in vivo team members.
• Evaluate, interpret, and compile LNP characterization data into study reports for company meetings.

Requirements of the Scientist – LNP Formulation:

• MS or PhD in Chemistry, Chemical Engineering, Biomedical Engineering, Bioengineering, Pharmaceutics, materials science or related field.
• Experience in making LNPs using Microfluidics, T-mixer, or other inline mixers.
• Experience with tangential flow filtration (TFF) and sterile filtration.
• Proficiency with related LNP/mRNA analytical techniques (e.g. plate-based fluorescence assays, HPLC, LC/MS).
• Attention to detail, ability to multitask, and complete deliverables within timelines.
• Strong written and verbal communication skills.