Job ID: #9010

Scientist, Renal Biology

Cambridge, MA
Science Science
Research & Development

 

Responsibilities of the Scientist, Renal Biology:

  • Contribute to target selection and validation for kidney diseases. Collaborate with internal stakeholders and external key opinion leaders.
  • Set up therapeutically relevant in vitro models for kidney, including iPSC-derived cultures and organoids.
  • Develop and implement target-specific assays and protocols for in vitro and in vivo phenotypic analysis.
  • Critically evaluate and apply new DNA base editor, RNA editor, or nuclease constructs to prospective disease targets, with an emphasis on renal disease.
  • Design and manage the execution of in vivo animal model studies for pharmacology and biodistribution.
  • Design and implement cloning strategies to construct plasmids for the production of mRNA and protein used in editing experiments.
  • Design and execute DNA/RNA purification and quantification assays (NGS, qPCR, and RNA-seq).

Requirements of the Scientist, Renal Biology:

  • PhD in cell or molecular biology, nephrology, or related discipline.
  • Industry experience is desirable but not required.
  • Extensive cell culture experience, including culturing and differentiating iPS cells.
  • Primary cell isolation and culture is a plus.
  • Experience with standard molecular and cell biology methods, and emerging technologies such as high-throughput sequencing and droplet digital PCR.
  • Familiarity with high-throughput screens.

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