Located in Cambridge, MA

Responsibilities of the Scientist/Sr. Scientist – Medicinal Chemistry:

• Will perform modern chromatographic and analytical techniques like TLC, column chromatography, HPLC, and NMR to purify and characterize organic compounds.
• Design and execute multi-step synthesis to prepare nucleic acid monomers, synthesize modified oligonucleotides, and perform bioconjugation of oligonucleotides to ligands.
• Perform synthesis, purification, and analysis of oligonucleotides including DNA, RNA and modified oligos or peptides.
• Provide clear written and verbal updates to project teams and management.
• Serve as chemistry lead on cross-functional project teams.

Requirements of the Scientist/Sr. Scientist – Medicinal Chemistry:

• Ph.D. in medicinal chemistry or a related discipline, and 0-3 years of relevant experience in industry or academia.
• Experience in nucleoside/oligonucleotide synthesis and purification.
• Experience with bioconjugation methods, including purification, and characterization.
• Oligonucleotide synthesis experience using automated DNA/RNA synthesizers is a plus.
• Demonstrable strong publication and/or patent track record of scientific excellence in the design and synthesis of bioactive compounds.