Job ID: #9414

Senior Associate Scientist/Scientist – Oligonucleotide Chemistry

Cambridge, MA
Science Science
Research & Development

Located in Cambridge, MA


Responsibilities of the Sr. Associate Scientist/Scientist – Oligonucleotide Chemistry:

  • Synthesis and biophysical analysis and characterization of oligonucleotides (RNA, ASOs, siRNAs, mRNA and gRNAs).
  • Characterization of small molecules and nucleic acids using NMR and LC-MS.
  • Developing analytical methods, and delivery systems with a focus on new modalities.
  • Planning and conducting experiments with minimum supervision; generating, evaluating, and reporting data clearly and reliably.
  • Providing data interpretation and making recommendations to project teams and other stakeholders.
  • Utilize specialized oligonucleotide synthesizers (e.g., Dr.Oligo, AKTA Oligopilot, Mermade) with oversight to produce high quality oligonucleotides.
  • Operate and maintain HPLC, and LC-MS for qualitative analysis and purification of synthetic oligonucleotides.
  • Critical analysis and evaluation of data to optimize synthesis yield, purity and formulation of modified oligonucleotides.
  • Quantitate compounds spectroscopically for in vitro and in vivo experiments.
  • Supply oligonucleotides for research and drug development programs according to priorities and timelines.


Requirements of the Sr. Associate Scientist/Scientist – Oligonucleotide Chemistry:

  • PhD. in Chemistry, Biochemistry, Chemical Engineering, or related field.
  • 3+ years of academic or industrial hands-on experience in oligonucleotide characterization.
  • Experience with the operation and maintenance of mass spectrometry equipment and the use of mass analysis software.
  • The ability to write custom macros in Excel for streamlining the reporting of results.
  • Exceptionally strong troubleshooting and problem-solving skills.

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