Job ID: #8467

Senior Research Associate, Process Development

Cambridge, MA
Science Science
GMP Manufacturing

 

Responsibilities of the Senior Research Associate, Process Development:

  • Conduct, troubleshoot, and modify experiments to reach desired goals and develop SOPs
  • Oversees raw materials preparation, buffer preparation and machine maintenance as it pertains to mRNA production and characterization
  • Complete standard analytical procedures on formulations and molecules of interest to ensure the quality of the material prior to further experimentation
  • Working closely with Analytical Development, assist in analytical development for in vitro transcribed mRNA
  • Work independently, as well as, collaborate with colleagues in support of project goals
  • Communicate research and development findings with internal teams
  • Apply efficient work-flows to ensure data and materials are available to internal and external groups in a timely manner
  • Adhere to all laboratory safety requirements and procedures
  • Begin to design and execute experiments through proper DoE method toward improvement and optimization of plasmid and mRNA production processes
  • Define and execute studies to identify critical process parameters through QbD, ensure robust process performances
  • Critically review and analyze data, communicate results, present findings and draft technical reports
  • Support development of standard operating procedures, technology transfer activities and documentation in support of regulatory filings

Requirements: of the Senior Research Associate, Process Development:

  • BA/BS in Biochemistry, Molecular Biology, Biomedical Engineering or related discipline with 3-5+ years of laboratory experience OR MS in Biochemistry, Molecular Biology, Biomedical; Engineering or related discipline with relevant experience
  • Experience in process development and production of biomacromolecules such as mRNA, pDNA, siRNA, proteins or viral gene therapy
  • Experience with multiple modes of separations method development including HPLC/UPLC, FPLC, TFF
  • Working knowledge of nucleic acid chemistry, enzymatic and chemical reactions, PCR, plasmid processing, and standard analytical techniques for macromolecules (e.g. electrophoresis, enzyme activity, ELISA, PCR)

 

Commonwealth Sciences is a professional recruiting firm specializing in Science, Engineering and Green Technologies. We unite industry professionals with exciting career opportunities by leveraging our technical expertise, advanced recruiting tools and years of staffing experience. CWS works with a variety of disciplines and levels from Research Associates to Scientists, Engineers, Managers and Directors. Our clients value the basic integrity, customer service and industry expertise that defines our organization.

Commonwealth Sciences, Inc.

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Commonwealth Sciences is a professional recruiting firm specializing in Science, Engineering and Green Technologies. We unite industry professionals with exciting career opportunities by leveraging our technical expertise, advanced recruiting tools and years of staffing experience. CWS works with a variety of disciplines and levels from Research Associates to Scientists, Engineers, Managers and Directors. Our clients value the basic integrity, customer service and industry expertise that defines our organization.